艾地苯醌联合多巴丝肼对帕金森病伴认知功能障碍患者认知功能和生活能力的影响

Effects of Idebenone Combined with Levodopaand Benserazide Hydrochlo-ride on Cognitive Function and Living Ability in Patients with Parkinson’s Disease Complicated with Cognitive Disorder

目的:探讨艾地苯醌联合多巴丝肼对帕金森病伴认知功能障碍患者认知功能和生活能力的影响。方法:选取2017年1月至2018年8月南宁市第三人民医院收治的帕金森病伴认知功能障碍患者102例,按照随机数字法分为观察组和对照组,每组51例。对照组患者在常规治疗的基础上加用多巴丝肼片,观察组患者在对照组的基础上加用艾地苯醌片。观察两组患者的临床疗效、日常生活能力、认知功能和安全性。结果:观察组患者的总有效率为88.24%(45/51),明显高于对照组的64.71%(33/51),差异有统计学意义(P<0.05)。治疗后,观察组严重依赖患者所占比例明显低于对照组,生活自理患者所占比例明显高于对照组,差异均有统计学意义(P<0.05);观察组患者MMSE总分明显高于对照组,差异有统计学意义(P<0.05);观察组中度认知功能障碍患者所占比例明显低于对照组,认知功能正常患者所占比例明显高于对照组,差异均有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为25.49%(13/51)、21.57%(11/51),差异无统计学意义(P>0.05)。结论:艾地苯醌联合多巴丝肼片治疗帕金森病的疗效显著,可明显改善患者的认知功能和生活能力,且安全性较好。

OBJECTIVE:To probe into the effects of idebenone combined with levodopaand benserazide hydrochlo-ride on cognitive function and living ability in patients with Parkinson's disease complicated with cognitive disorder.METHODS:102 patients with Parkinson's disease complicated with cognitive disorder admitted into the Third People's Hospital of Nanning from Jan.2017 to Aug.2018 were selected and divided into observation group and control group via random number table,with 51 cases in each group.The control group was treated with lLevodopaand benserazide hydrochlo-ride tablets based on conventional therapy,while the observation group was given Idebenone tablets based on the control group.The clinical efficacy,activity of daily living,cognitive function and safety of two groups were observed.RESULTS:The total effective rate of observation group was 88.24%(45/51),which was significantly higher than that of the control group(64.71%,33/51),with statistically significant difference(P<0.05).After treatment,the proportion of patients who were heavily dependent in observation group was significantly lower than that of the control group,and the proportion of self-care patients was significantly higher than that of the control group,with statistically significant differences(P<0.05);the MMSE scores of observation group was significantly higher than that of the control group,with statistically significant difference(P<0.05);the proportion of patients with medium cognitive disorder in observation group was significantly lower than that of the control group,the proportion of patients with normal cognitive function in observation group was significantly higher than that of the control group,with statistically significant differences(P<0.05).The incidences of adverse drug reaction of observation group and control group were respectively 25.49%(13/51)and 21.57%(11/51),the difference had no statistical significance(P>0.05).CONCLUSIONS:The efficacy of idebenone combined with levodopaand benserazide hydrochlo-ride in treatment of Parkinson's disease is remarkable,which can significantly improve patients cognitive function and living ability,with high safety.