干扰素α-2b的全球专利技术路线分析

Analysis of Foreign and Chinese Patent in IFN α-2b

干扰素α-2b是一种重要的广谱抗病毒、抗肿瘤治疗药物。本文针对干扰素α-2b存在的稳定性差、半衰期短、毒副作用等问题,分别从构建突变体、与人血清白蛋白HSA融合、与Fc融合、PEG修饰等方面对干扰素α-2b技术发展脉络进行专利分析。

Interferonα-2b(IFNα-2b)is an important broad-spectrum antiviral and anti-tumor drug.Aiming at the problems of poor stability,short half-life and side effects of IFNα-2b,this paper analyzed the development of IFNα-2b technology from the aspects of mutant construction,fusion with human serum albumin,fusion with Fc and PEG modification.