摘要
以奥贝胆酸为原料,与二甲羟胺盐酸盐缩合反应后,经硼氢化锂还原得到3α,7α-二羟基-6α-乙基-5β-胆烷-24-醇(3)。目标化合物经核磁确证。该方法工艺操作简便,反应条件温和,转化率高。
After condensing with dimethylhydroxylamine hydrochloride by using obeticholic acid as raw material,it is reduced by lithium borohydride to obtain 3α,7α-dihydroxy-6α-ethyl-5β-cholane-24-ol(3).The target compound was confirmed by nuclear magnetic resonance.The method has simple process,mild reaction condition and high conversion rate.
作者
古亮
刘晓斌
彭冠
陈辉
付敏
Gu Liang;Liu Xiaobin;Peng Guan;Chen Hui;Fu Min(Jiangxi Qingfeng Pharmaceutical Co.,Ltd.,Ganzhou 341000;Jiangxi Kewei Collaborative Innovative Pharmaceutical Co.,Ltd.,Ganzhou 341000,China)
出处
《广东化工》
CAS
2019年第22期43-44,共2页
Guangdong Chemical Industry
基金
江西省创新驱动“5511”工程资助项目(20165ABC28011)
江西省重点研发计划资助项目(20171ACG70014)
