血清炎症因子与特发性颅内高压患者近期视力下降的相关性研究

Relationship of Serum Inflammatory Factor and Recent Visual Impairment in Idiopathic Intracranial Hypertension

目的探讨特发性颅内高压(idiopathic intracranial hypertension,IIH)患者入院时炎症指标与近期视力下降的相关性。方法对2011年9月-2018年9月在首都医科大学附属北京天坛医院血管神经病学科诊治的58例IIH患者临床资料进行回顾性分析。根据患者入院时近1个月内是否出现视力下降,分为近期视力下降组(13例)和非近期视力下降组(45例)。应用秩和检验比较两组患者的血清超敏C反应蛋白(hypersensitive C reactive protein,hs-CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、白细胞绝对值、中性粒细胞绝对值、淋巴细胞绝对值、中性粒细胞/淋巴细胞比值等炎症指标的差异。结果近期视力下降组血清hs-CRP及ESR水平显著高于非近期视力下降组[5.50(3.35~8.45)vs 2.60(2.10~2.90)mg/L,P<0.001;18.0(13.0~24.0)vs 11.0(5.0~14.5)mm/h,P<0.032];而血清白细胞绝对值、中性粒细胞绝对值、淋巴细胞绝对值及中性粒细胞/淋巴细胞比值在两组间差异无统计学意义。结论在IIH患者中,存在近期视力下降的患者血清hs-CRP及ESR水平更高,提示炎症反应可能参与IIH患者视力障碍病程的急性进展。

Objective To investigate the correlation between serum inflammatory factor level and recent visual impairment in patients with idiopathic intracranial hypertension(IIH).Methods Clinical data of 58 patients with IIH who were hospitalized in Department of Neurology,Beijing Tian Tan Hospital from September 2011 to September 2018 were retrospectively analyzed.According to whether patients had visual impairment or not within recent 1 month on admission,they were divided into the recent visual impairment group(n=13)and non-recent visual impairment group(n=45).Kruskal-Wallis test was used to compare the difference of serum hypersensitive C reactive protein(hs-CRP),erythrocyte sedimentation rate(ESR),white blood cell counts,neutrophile granulocyte cell counts,lymphocyte cell counts and neutrophile granulocyte/lymphocyte cell ratio and other inflammatory indicators between the two groups.Results Serum hs-CRP and ESR level in the recent visual impairment group were significantly higher than that in non-recent visual impairment group[5.50(3.35-8.45)vs 2.60(2.10-2.90)mg/L,P<0.001;18.0(13.0-24.0)vs 11.0(5.0-14.5)mm/h,P<0.032,respectively],while the other inflammatory indicators between the two groups had no statistical difference.Conclusions The serum hs-CRP and ESR level in IIH patients with recent visual impairmentincreased significantly, which suggested that inflammatory response may be involved in thepathogenesis of acute progressive visual impairment in IIH patients.