趋化因子CX3CL1在脑缺血中的作用及机制

Roles and mechanisms of chemokine CX3CL1 in cerebral ischemia

趋化因子CX3CL1主要通过激活其受体CX3CR1参与神经系统生理和病理过程。生理状态下,CX3CL1可抑制小胶质细胞激活;脑缺血缺氧时,CX3CL1可影响涉及腺苷受体激活、抑制Ca2+内流、促进血管生长等途径的多个下游靶基因表达,对改善脑缺血后能量代谢障碍以及在梗死灶周围建立微循环具有重要的意义。

Chemokine CX3CL1 mainly participates in the physiological and pathological processes of nervous system by activating its receptor CX3CR1.Under physiological conditions,CX3CL1 can inhibit the activation of microglia;when cerebral ischemia and hypoxia,CX3CL1 can affect the expression of multiple downstream target genes involved in activation of adenosine receptor,inhibition of Ca2+influx,and promotion of blood vessel growth.It is of great significance to improve the energy metabolism disorder and to establish microcirculation around infarcts after cerebral ischemia.