利拉鲁肽联合盐酸二甲双胍治疗多囊卵巢综合征伴糖脂代谢紊乱的临床效果

Clinical effect of Lilalutide combined with Metformin Hydrochloride in the treatment of polycystic ovary syndrome with glycolipid metabolism disorder

目的探讨利拉鲁肽联合盐酸二甲双胍治疗多囊卵巢综合征(PCOS)伴糖脂代谢紊乱的临床效果。方法选取2017年1月~2019年1月我院收治的84例PCOS伴糖脂代谢紊乱患者作为研究对象,按照随机数字表法分为研究组和对照组,每组各42例。对照组口服盐酸二甲双胍,研究组在对照组基础上联合利拉鲁肽治疗。比较两组治疗前后的血脂、血糖各指标水平及不良反应总发生率。结果研究组治疗后的三酰甘油(TG)、低密度脂蛋白胆固醇(LDC-C)和总胆固醇(TC)水平低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组,差异均有统计学意义(P<0.05);研究组治疗后的餐后2 h血糖(2 h PG)、空腹血糖(FPG)和糖化血红蛋白(HbA1c)水平低于对照组,差异均有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论利拉鲁肽联合盐酸二甲双胍可有效改善PCOS伴糖脂代谢紊乱患者的血脂和血糖水平,促进病情缓解,值得临床推广应用。

Objective To explore the clinical effect of Lilalutide combined with Metformin Hydrochloride in the treatment of polycystic ovary syndrome(PCOS)with glycolipid metabolism disorder.Methods A total of 84 PCOS patients with glucose and lipid metabolism disorder from January 2017 to January 2019 were selected as the study objects,they were divided into the study group and the control group according to the random number table method,42 cases in each group.The control group was given Metformin Hydrochloride orally,and the study group was treated with Lilalutide on the basis of the control group.The levels of blood lipid,blood glucose before and after treatment and the total incidence of adverse reactions were compared between the two groups.Results The levels of TG,LDC-C and TC in the study group were lower than those in the control group,and HDL-C was higher than that in the control group,the differences were statistically significant(P<0.05).The levels of blood glucose(2 h PG),fasting blood glucose(FPG)and HbA1c in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lilaluptide combined with Metformin Hydrochloride can effectively improve the blood lipid and blood glucose level of PCOS patients with glycolipid metabolism disorder,and promote the remission of the disease,which is worthy of clinical application.