异丙托溴铵雾化吸入辅助治疗儿童急性喘息性支气管炎的效果

Effect of Ipratropium Bromide Aerosol Inhalation in the adjuvant treatment of acute asthmatic bronchitis in children

目的探讨异丙托溴铵雾化吸入辅助治疗儿童急性喘息性支气管炎的效果。方法选取2017年9月~2019年2月我院接诊的156例急性喘息性支气管炎患儿作为研究对象,按照给药方式的不同分为对照组和联合组,每组各78例。对照组雾化吸入布地奈德与硫酸特布他林进行治疗,联合组在对照组基础上雾化吸入异丙托溴铵进行治疗。比较两组的临床治疗效果、症状体征消退时间及药物不良反应发生情况,并比较两组治疗前后的血清降钙素原(PCT)和血清C-反应蛋白(CRP)水平。结果联合组的治疗总有效率为97.44%,高于对照组的80.77%,差异有统计学意义(P<0.05)。联合组的喘息、咳嗽、肺部哮鸣音及肺部湿啰音消退时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗前的血清PCT和CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组的PCT和CRP水平低于治疗前,联合组的PCT和CRP水平低于对照组,差异均有统计学意义(P<0.05)。两组患儿治疗过程中均未出现明显的不良反应。结论异丙托溴铵雾化吸入辅助治疗儿童急性喘息性支气管炎的效果较好,不仅可明显改善患儿的临床症状和体征,缓解炎症反应,且安全性较高,值得临床推广应用。

Objective To explore the effect of Ipratropium Bromide Aerosol Inhalation in the adjuvant treatment of acute asthmatic bronchitis in children.Methods A total of 156 children with acute asthmatic bronchitis in our hospital from September 2017 to February 2019 were selected as the study objects,they were divided into control group and combined group according to the different ways of administration,78 cases in each group.The control group was treated with Budesonide and Terbutaline Sulfate,and the combined group was treated with Ipratropium Bromide on the basis of the control group.The clinical therapeutic effect,the time of symptom and sign regression and the occurrence of adverse drug reactions were compared between the two groups.The levels of serum procalcitonin(PCT)and serum C-reactive protein(CRP)before and after treatment were compared between the two groups.Results The total effective rate of the combined group was 97.44%,higher than 80.77%of the control group,the difference was statistically significant(P<0.05).The time of wheezing,coughing,wheezing and moist rale in the combined group were shorter than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in serum PCT and CRP levels between the two groups before treatment(P>0.05).After treatment,the levels of PCT and CRP in the two groups were lower than those before treatment,and the levels of PCT and CRP in the combined group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant adverse reaction in the two groups.Conclusion The effect of Ipratropium Bromide atomization inhalation in the treatment of children with acute asthmatic bronchitis is better.It can not only improve the clinical symptoms and signs of children,alleviate the inflammatory reaction,but also has a high safety,which is worth clinical application.