小剂量阿司匹林治疗妊娠期血液高凝的临床效果

Clinical effect of low dose Aspirin in the treatment of hypercoagulability blood in pregnancy

目的探讨小剂量阿司匹林治疗妊娠期血液高凝的临床效果。方法选取2017年3月~2019年1月我院收治的72例妊娠期血液高凝患者作为研究对象,采用奇偶分组法分为对照组(36例)和观察组(36例)。对照组采用硫酸镁治疗,观察组采用口服小剂量阿司匹林治疗。比较两组的不良分娩结局总发生率、凝血指标、新生儿不良结局总发生率及心理状态评分。结果观察组的不良分娩结局总发生率低于对照组,差异有统计学意义(P<0.05);治疗后,两组的血小板计数、纤维蛋白原及D-二聚体水平低于治疗前,观察组的血小板计数、纤维蛋白原及D-二聚体水平低于对照组,差异均有统计学意义(P<0.05);观察组的新生儿不良结局总发生率低于对照组,差异有统计学意义(P<0.05);观察组的焦虑、抑郁评分低于对照组,差异均有统计学意义(P<0.05)。结论妊娠期血液高凝患者口服小剂量阿司匹林进行治疗,可有效改善患者的血液高凝状态,减少不良妊娠结局和新生儿不良结局的发生,缓解患者的负面情绪。

Objective To explore the clinical effect of low dose Aspirin in the treatment of hypercoagulability blood in pregnancy.Methods A total of 72 pregnant women with hypercoagulability blood in our hospital from March 2017 to January 2019 were selected as the study objects,they were divided into control group(36 cases)and observation group(36 cases)by odd even grouping method.The control group was treated with Magnesium Sulfate,and the observation group was treated with low dose Aspirin.The total incidence of adverse delivery outcome,coagulation index,the total incidence of adverse neonatal outcomes and the score of psychological state were compared between the two groups.Results The total incidence of adverse delivery outcome in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the platelet count,fibrinogen and D-dimer levels in the two groups were lower than those before treatment,the platelet count,fibrinogen and D-dimer levels in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse outcomes in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The scores of anxiety and depression in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Low dose Aspirin can effectively improve the hypercoagulability blood of patients,reduce the adverse pregnancy outcome and neonatal adverse outcome,and alleviate the negative emotions of patients.