槟榔依赖的神经影像学

Neuroimaging of Betel quid dependence

槟榔依赖(Betel quid dependence,BQD)是一种以失去自我控制、强迫性反复用药为特征的慢性复发性脑疾病,符合世界卫生组织归纳的成瘾行为特征.长期嚼食会增加口腔癌等多种肿瘤的患病风险,但BQD尚缺乏理想的动物模型、其成瘾机制不清,尚无有效预防及治疗方法.神经影像学新技术为探讨BQD神经机制提供了一种无创、可定量的评估方法.回顾近年来BQD神经机制及其影像学研究进展,这些研究为BQD脑改变提供了初步客观证据,有助于深入认识其发病的神经机制,并为开展早期干预及治疗提供理论依据.

Betel quid dependence(BQD)is a chronic recurrent brain disease characterized by loss of self-control and compulsive repeated use of drugs,which conforms to the characterics of addictive behavior classified by the World Health Organization. Long term chewing Betel nut can increase the risk of a variety of cancers such as oral cancer. The BQD research lacks the ideal animal model whereas the mechanism of BQD is still not clear,and there is no effective treatment and prevention. Notably,neuroimaging technology has provided a non-invasive,quantitative assessment method for the neural mechanism of BQD. The author sum-marized the neural mechanism and imaging studies progress of BQD,and these findings provided preliminary objective evidence for the brain changes of BQD,which was helpful for the deep understanding of the neuro-pathic mechanism of BQD,and provided theoretical basis for the early intervention and treatment.