牛蒡苷元在仔猪体内的药物动力学研究

Pharmacokinetics of Arctiin in Piglets

为研究牛蒡苷元在仔猪体内的药物动力学特征,了解其在仔猪体内的吸收、分布、转化和排泄规律,为新兽药的研发和临床用药提供理论参考依据。选取健康仔猪8头(30.0±5.0 kg),以2.0 mg/kg.bw的牛蒡苷元静脉注射给药,不同时间点前腔静脉采血,采用HPLC法对猪血浆中牛蒡苷元的浓度进行分析。牛蒡苷元静脉注射后,符合无吸收二室模型,主要药动学参数为:分布半衰期(t1/2α)0.166±0.022 h;消除半衰期(t1/2β)3.161±0.296 h;表观分布容积(Vd)0.231±0.033 L/kg;清除率(CLb)0.057±0.003 L/(h·kg);药时曲线下面积(AUC)1.189±0.057μg·h·m L-1。由此可知,牛蒡苷元静脉注射后在仔猪体内分布迅速、分布组织较少、代谢消除较快。

The experiment was carried out in order to study the pharmacokinetic characteristics of arctidine in piglets,understand its absorption,distribution,transformation and excretion regulation in piglets,and provide theoretical reference for the development and clinical use of new veterinary drugs.Eight healthy piglets(30.0±5.0kg)were injected with arctigan at 2.0 mg/kg.bw intravenously,and blood was collected from the anterior vena cava at different time points.The concentration of arctigan in pig plasma was analyzed by HPLC.After intravenous injection of arctiin,the main pharmacokinetic parameters were:distribution half-life(t1/2)0.166±0.022 h;Elimination half-life(t1/2)3.161±0.296 h;Apparent volume of distribution(Vd)0.231±0.033 L/kg;Clearance rate(CLb)0.057±0.003 L/(h·kg);The AUC was 1.189±0.057 g·h·mL-1.The results showed that burdock glycosides were rapidly distributed except for human organ together with high metabolism in piglets after intravenous injection.