米非司酮口服联合乳酸依沙吖啶羊膜腔内注射在瘢痕子宫妊娠孕妇终止妊娠中的应用

Application of Oral Mifepristone Combined with Ethacridine Lactate in Amniotic Cavity Injection for Termination of Pregnancy in Pregnant Women with Scar Uterus

目的:探讨瘢痕子宫妊娠患者采用米非司酮联合乳酸依沙吖啶引产的疗效及安全性。方法:随机将2015年1月~2017年2月收治的80例瘢痕子宫妊娠孕妇分为两组,A组采用乳酸依沙吖啶羊膜腔内注射治疗,B组在此基础上联合米非司酮治疗,比较两组的引产效果及其他观察指标状况。结果:B组用药至宫缩时间、用药至胎儿娩出时间、出血量与不良反应发生率明显少于A组,引产成功率明显高于A组,组间对比差异有统计学意义(P<0.05)。结论:乳酸依沙吖啶联合米非司酮治疗瘢痕子宫妊娠,能有效提高引产成功率,缩短产程,减少引产出血量和不良反应,适合临床推广。

Objective:To investigate the efficacy and safety of mifepristone combined with ethacridine lactate in amniotic cavity injection for termination of pregnancy in pregnant women with scar uterus.Methods:80 cases of pregnant women with scar uterus admitted from January 2015 to February 2017 were randomly divided into two groups.Group A was treated with amniotic injection of ethacridine lactate.Group B was combined with mifepristone on this basis,compared the effect of induction of labor and other observation indexes in the two groups.Results:The time from drug using to uterine contraction time,the time from pharmacy to delivery he fetus,the bleeding amount and the rate of adverse reactions in group B were significantly less than that of the group A.The success rate of induction was significantly higher than that in the group A,and the difference between the groups was statistically significant(P<0.05).Conclusion:The combination of ethacridine lactate and mifepristone in the treatment of scar uterine pregnancy can effectively improve the success rate of induced abortion,shorten the course of labor,reduce the amount of bleeding and adverse reactions,and is suitable for clinical application.