扩张型心肌病患者血清CA125、Hcy水平及其对预后的预测价值

Serum CA125 and Hcy levels in patients with dilated cardiomyopathy and the predictive value in prognosis

目的检测扩张型心肌病(DCM)患者血清糖类抗原125(CA125)、同型半胱氨酸(Hcy)水平并分析其对预后的预测价值。方法回顾性分析84例DCM患者的临床资料,检测血清CA125、Hcy水平,并分析其对DCM预后的预测作用。结果 84例DCM患者中26例(30.95%)发生心源性死亡。A组心功能Ⅲ~Ⅳ级、VT、P-选择素>20.8μg/L、CA125>40.0 kU/L、Hcy>15.0μmol/L的患者占比均高于B组,差异具有统计学意义(P<0.05),经多因素Logistic回归分析证实上述指标均为DCM患者心源性死亡的独立危险因素(P<0.05)。结论 DCM患者心源性死亡的影响因素较多,血清CA125、Hcy水平为其独立危险因素,可作为预后评估指标。

Objective To detect the levels of serum carbohydrate antigen 125(CA125) and homocysteine(Hcy) in patients with dilated cardiomyopathy(DCM) and analyze the predictive value in prognosis. Methods The clinical data of 84 patients with DCM were retrospectively analyzed, the serum CA125 and Hcy levels were measured, and the predictive effect of prognosis of DCM was analyzed. Results There were 26 cases(30.95%) had cardiogenic death in 84 patients with DCM. The serum CA125 and Hcy levels in the group A were higher than those in the group B. The proportion of patients with cardiac function grade Ⅲ~Ⅳ, VT, P-selectin>20.8 μg/L, CA125>40.0 kU/L, Hcy>15.0 μmol/L in the group A were higher than those in the group B, the differences were statistically significant(P<0.05), and multivariate Logistic regression analysis confirmed that the above indexes were independent risk factors of cardiogenic death in DCM patients(P<0.05).Conclusion Cardiac death in DCM patients has many influencing factors, and serum CA125 and Hcy levels are independent risk factors, which can be used as indexes for prognostic assessment.