玉屏风颗粒联合锌剂辅助治疗小儿反复呼吸道感染的效果

Effect of Yupingfeng granule combined with zinc in the adjuvant treatment of recurrent respiratory tract infection in children

目的研究玉屏风颗粒联合锌剂治疗小儿反复呼吸道感染的效果及对炎症反应及免疫功能的影响。方法选择我院2017年1月至2018年6月收治的70例反复呼吸道感染患儿为研究对象,根据随机数字表法将其分为对照组(n=35)和观察组(n=35)。对照组给予常规治疗,观察组给予常规治疗+玉屏风颗粒联合锌剂治疗。比较两组的临床症状改善情况、临床疗效、炎症反应及免疫功能。结果观察组患儿的发热、咳嗽、咽红、肺部啰音消失时间均短于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为94.29%,高于对照组的74.29%,差异具有统计学意义(P<0.05)。治疗后,两组患儿的CRP、TNF-α水平均降低,IL-2水平均升高,且观察组优于对照组(P<0.05)。治疗后,两组患儿的IgA、IgG及IgM水平均升高,且观察组高于对照组(P<0.05)。结论在常规治疗的基础上辅以玉屏风颗粒联合锌剂治疗有助于反复呼吸道感染患儿临床疗效及免疫功能的提高,可有效改善患儿的临床症状,减轻炎症反应。

Objective To study the effect of Yupingfeng granule combined with zinc in the adjuvant treatment of recurrent respiratory tract infection in children and its influence on inflammatory reaction and immune function. Methods Seventy children with recurrent respiratory tract infection admitted in our hospital from January 2017 to June 2018 were selected as the study objects. And the children were divided into control group(n =35) and observation group(n =35)according to the random number table method. The control group was given routine treatment, the observation group was given routine treatment + Yupingfeng granules combined with zinc treatment. The improvement of clinical symptoms,clinical efficacy, inflammatory response and immune function were compared between the two groups. Results The disappearance time of fever, cough, pharyngeal red and lung rale in the observation group were shorter than those in the control group, and the differences were statistically significant(P <0.05). The total effective rate of treatment in the observation group was 94.29%, which was higher than 74.29% in the control group, and the difference was statistically significant(P <0.05). After treatment, the levels of CRP and TNF-α in the two groups decreased, the levels of IL-2 increased, and those in the observation group were better than the control group(P<0.05). After treatment, the levels of IgA, IgG and IgM in the two groups all increased, and those in the observation group were higher than the control group(P<0.05). Conclusion Yupingfeng granule combined with zinc on the basis of routine treatment can enhance the clinical efficacy and immune function of children with recurrent respiratory tract infection, improve effectively the clinical symptoms and reduce the inflammatory response of children.