网织红细胞参数在白血病化疗前后的意义

Significance of Reticulocyte Parameters before and after Chemotherapy for Leukemia

目的:研究急性白血病化疗前后网织红细胞参数变化的临床意义。方法:12例急性白血病化疗的患者,分别于化疗前后不同时段,用自动化血液分析仪检测患者的网织红细胞绝对值(RET#)、网织红细胞比率(RET%)、未成熟网织红细胞比率(IRF)、白细胞(WBC)、中性粒细胞绝对值(NEUT)。结果:急性白血病化疗患者化疗后RET#、RET%、IRF、WBC、NEUT都出现降低,IRF从化疗后第4天起即显著降低,RET#、RET%从化疗后第7天起即显著降低,WBC和NEUT在化疗后第10天显著降低;而IRF、RET#在化疗的第13天起明显升高,RET%、WBC、NEUT在化疗后第16天开始明显回升。结论:IRF是反应骨髓抑制和恢复的敏感指标。

Objective:To study the clinical significance of reticulocyte parameters in acute leukemia before and after chemotherapy.Methods:The absolute reticulocyte count(RET), reticulocyte ratio(RET%), immature reticulocyte ratio(IRF),white blood cell(WBC) and neutrophil absolute value(NEUT) were measured by automated blood analyzer in 12 patients with acute leukemia before and after chemotherapy.Results:After chemotherapy, RET,RET,IRF,WBC and NEUT in patients with acute leukemia decreased significantly. IRF decreased significantly from the 4 th day after chemotherapy, RET and RET% decreased significantly from the 7 th day after chemotherapy, WBC and NEUT decreased significantly on the 10 th day after chemotherapy, while IRF and RET increased significantly after 13 days of chemotherapy, RET%,WBC,NEUT began to increase significantly on the 16 th day after chemotherapy.Conclusion:IRF is a sensitive index for bone marrow suppression and recovery.