视网膜静脉阻塞伴黄斑水肿抗VEGF治疗预后影响因素研究

Factors affecting prognosis of retinal vein occlusion with macular edema after anti-VEGF treatment

目的研究影响视网膜静脉阻塞(RVO)合并黄斑水肿(ME)患者的黄斑中心视网膜厚度(CRT)的相关因素。方法采用回顾性对照研究。我院眼科2017年3月~2019年4月就诊的视网膜静脉阻塞伴黄斑水肿患者共67例(67眼),收集其初次发病的详细病史及治疗3个月后的随访数据,并进行单因素分析和多因素Logistic回归分析。结果病程以及基线CRT是治疗3个月后影响黄斑中心视网膜厚度的因素。结论各因素中基线CRT和病程在3个月后对患者CRT的改变具有统计学意义,这些基线因素可以帮助临床医生预测RVO伴ME患者的预后情况。

Objective To investigate factors affecting the central retinal thickness(CRT)in patients with retinal vein occlusion(RVO)complicated with macular edema(ME).Methods A total of 67 patients(67 eyes)with RVO and macular edema from Mar 2017 to Apr 2019 in our hospital were enrolled.The data of the first onset and the follow-up data after 3 months of treatment were included in univariate and multivariate Logistic regression analysis.Results After 3 months of treatment,duration of disease and baseline CRT were the factors which influenced central retinal thickness.Conclusion Baseline CRT and duration of disease are statistically significant in patients with CRT changes after 3 months.These baseline factors can contribute to predict the prognosis of patients with RVO and ME.