正常人黄斑区神经节细胞复合体厚度对称性分析

Interocular symmetry of ganglion cell complex thickness in normal healthy subjects

目的:研究正常人群黄斑区神经节细胞复合体(mGCC)厚度的对称性,确定双眼mGCC厚度差值的临界点。方法:横断面研究。采用光学相干断层扫描技术(OCT)检测236例472眼自愿接受检查的健康志愿者双眼mGCC厚度,分析双眼mGCC厚度的差异及相关性,计算双眼mGCC厚度差值的临界点。结果:本组研究对象右眼平均mGCC厚度为91.99±6.61μm,左眼为91.75±9.93μm;右眼上方和下方mGCC厚度分别为92.32±6.66、91.27±8.87μm,左眼分别为92.05±6.55、91.51±6.76μm,双眼各区域mGCC厚度均相当。双眼平均mGCC厚度差值P 2.5、P 97.5分别为-4.82、4.36μm,上方mGCC厚度差值分别为-5.79、6.42μm,下方mGCC厚度差值分别为-7.21、6.28μm。双眼对应区域mGCC厚度均具有较强相关性。结论:正常人双眼mGCC厚度对称,当双眼mGCC厚度差值超过正常范围时,可认为呈不对称状态,需要警惕青光眼的发生。

AIM:To investigate interocular differences in macular ganglion cell complex(mGCC)thickness in normal healthy subjects,and to determine cutoffs for interocular differences in mGCC thickness in normal healthy subjects.METHODS:This was a cross-sectional study.mGCC thickness were measured in 236 healthy volunteers(472 eyes)using optical coherence tomography(OCT).The differences and the relationships of mGCC thickness between right and left eyes were analyzed.RESULTS:For the right eyes,the mean average mGCC thickness was 91.99±6.61μm,and for the left,91.75±9.93μm,with no significant difference.The mean mGCC thickness among superior and inferior in the right eye were 92.32±6.66μm and 91.27±8.87μm,respectively.The mean mGCC thickness among superior and inferior in the left eye were 92.05±6.55 and 91.51±6.76μm,respectively.It is comparable between the two eyes at different area.The P 2.5 and P 97.5 percentiles of interocular difference for mean average mGCC thickness were-4.82μm and 4.36μm,for superior mGCC thickness,-5.79μm and 6.42μm,and for inferior mGCC thickness,-7.21μm and 6.28μm.There was a strong correlation in the corresponding area between the right and left eyes for the mGCC thickness.CONCLUSION:mGCC thickness shows significant interocular symmetry in normal subjects.Interocular difference exceeding the normal limits should be considered significantly asymmetrical,and may be indicative of glaucoma.