快速荧光扩散断层成像的格子玻尔兹曼前向模型

A Lattice Boltzmann Forward Model for Fast Fluorescence Diffuse Optical Tomography

荧光扩散断层成像(Fluorescence Diffuse Optical Tomography,FDOT)作为一种新型成像技术,能对生物组织体内的病变区域进行三维定量的功能成像,在生物医学中具有广泛的应用价值。合理描述光在生物组织内传播的前向模型是实现FDOT的前提,并决定着该成像技术的性能。为提高FDOT的成像效率,该文通过辐射传输方程离散求解,提出了一种新型的基于格子玻尔兹曼(Lattice Boltzmann,LB)方法的前向模型,并用于实现FDOT。数值仿体和物理仿体的验证实验结果表明,该文提出的LB前向模型,较传统扩散方程方法,能将FDOT的成像速度提高5倍左右,而不会降低其成像质量。

Fluorescent Diffuse Optical Tomography(FDOT),as a new imaging technology,can achieve three-dimensional quantitative functional imaging of probe in biological tissues,and has wide application value in biomedicine.Forward model which describes the photon propagation within a biological tissue is a prerequisite for implementing FDOT and determines the performance of FDOT.To further improve the efficiency of FDOT,this paper proposes a new forward model based on the Lattice Boltzmann(LB)method derived from the discretization of radiation transfer equation and applies it to FDOT.The experimental results of numerical simulation and physical phantom show that the LB-based forward model proposed in this paper can increase the imaging speed of FDOT by about 5 times compared with the traditional diffusion equation method,without reducing its imaging quality.