血管紧张素Ⅱ1型受体在口腔鳞癌中的表达及临床意义

Expression and clinical significance of AT1 receptor in oral squamous cell carcinoma

目的研究血管紧张素Ⅱ1型受体(AT1受体)在口腔鳞癌组织中的表达及其临床意义。方法收集2012年1—12月期间在南京市口腔医院46例经术后常规病理确诊为口腔鳞癌的病人的石蜡组织切片,其中20例切片中包含了正常的癌旁组织。采用免疫组织化学方法检测46例口腔鳞癌组织和20例相邻癌旁组织中AT1受体的表达。结果20例正常癌旁组织中AT1受体阳性率为15.0%,低于口腔鳞癌组织中阳性率(89.1%)(χ^2=109.696,P<0.01)。AT1受体在口腔鳞癌组织中低表达14例,高表达27例,高表达的AT1受体与病人的性别、年龄无关,与原发肿瘤大小、颈部淋巴组织转移及临床分期密切相关。结论AT1受体在口腔鳞癌组织中高表达,有可能作为口腔鳞癌的诊断和预后的指标。

Objective To study the expression and clinical significance of angiotensinⅡtype 1(AT1)receptor in oral squamous cell carcinoma.Methods From January to December 2012 in Nanjing Stomatological Hospital,immunohistochemistry was used to detect the expression of AT1 receptor in 46 cases of oral squamous cell carcinoma and 20 adjacent paracancerous tissues.Results The positive rate of AT1 receptor was 15.0%in 20 adjacent paracancerous tissues,lower than that in oral squamous cell carcinoma(89.1%)(χ^2=109.696,P<0.01).There were 14 cases low expression and 27 cases high expression of AT1 receptor in oral squa mous cell carcinoma.The high expression of AT1 receptor was not related to gender and age of patients,and was closely related to primary tumor size,cervical lymphoid tissue metastasis and clinical stage.Conclusion AT1 receptor was highly expressed in oral squamous tissue and may be used as an indicator for the diagnosis and prognosis of oral squamous cell carcinoma.