肿瘤标志物的参考变化值和参考变化因子比较

Comparative study on reference change values and reference change factors of tumor markers

目的计算7项肿瘤标志物[甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原(CA)125、CA15-3、CA19-9、游离前列腺特异性抗原(f-PSA)、总前列腺特异性抗原(t-PSA)]的参考变化值(RCV)和参考变化因子(RCF)。方法根据公式计算RCV及参考变化上限因子(RCFup)和参考变化下限因子(RCFdown)的单向范围和双向范围。结果根据公式计算出AFP、CEA、CA125、CA15-3、CA19-9、f-PSA、t-PSA的RCV和RCF。结论建议临床实验室同时使用RCV和RCF作为健康人群的参考区间。在连续监测肿瘤患者相关指标时将RCF作为临床动态判读的方法。

Objective To calculate the reference change values(RCV)and reference change factors(RCF)of 7 tumor markers[alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,CA15-3,CA19-9,free prostate-specific antigen(f-PSA)and total prostate-specific antigen(t-PSA)].Methods The unidirectional ranges and bidirectional ranges of RCV and RCF reference change upper limit factor(RCFup)and reference change lower limit factor(RCFdown)were calculated.Results The RCV and RCF of AFP,CEA,CA125,CA15-3,CA19-9,f-PSA and t-PSA were calculated according to the formulas.Conclusions It is recommended that clinical laboratories use both RCV and RCF as reference intervals for healthy subjects.RCF is used as a method for clinical dynamic interpretation when continuously monitoring related indicators of tumor patients.