腹腔镜与促性腺激素释放激素激动剂联合治疗子宫内膜异位症伴不孕症的疗效

Effect of Laparoscopy Combined with Gonadotropin Releasing Hormone Agonist in the Treatment of Endometriosis with Infertility

目的探讨腹腔镜与促性腺激素释放激素激动剂(GnRH-a)联合治疗子宫内膜异位症伴不孕症的效果。方法选取2016年5月至2017年5月渭南市临渭区妇幼保健计划生育服务中心收治的子宫内膜异位症伴不孕症患者82例,以随机数表法将其分为对照组与研究组,各41例。对照组行腹腔镜治疗,研究组在此基础上应用促性腺激素释放激素激动剂(GnRH-a)治疗。术后6个月时,比较两组临床疗效;随访12个月,评价两组妊娠率与疾病复发率。结果研究组治疗的总有效率显著高于对照组(95.12%vs.78.05%,P<0.05)。研究组1年内的妊娠率高于对照组(60.98%vs.34.15%,P<0.05),疾病复发率低于对照组(4.88%vs.19.51%,P<0.05)。结论腹腔镜与GnRH-a联合治疗子宫内膜异位症伴不孕症不仅疗效确切,并可以提高妊娠率,适于推广。

Objective To investigate the effect of laparoscopy combined with gonadotropin releasing hormone agonist(GnRH-a)in the treatment of endometriosis with infertility.Methods A total of 82 patients with endometriosis and infertility admitted to the Maternal and Child Health Family Planning Service Center in Linwei District of Weinan City were selected from May 2016 to May 2017.They were randomly divided into control group and research group,41 cases in each group.The control group was treated with laparoscopy,and the study group was treated with laparoscopy combined with GnRH-a.At 6 months after operation,the clinical effects of the two groups were compared,and the pregnancy rate and disease recurrence rate of the two groups were evaluated after 12 months of follow-up.Results The total effective rate of the study group was significantly higher than that of the control group(95.12%vs.78.05%,P<0.05).The pregnancy rate in the study group was higher than that in the control group(60.98%vs.34.15%,P<0.05),and the recurrence rate was lower than that in the control group(4.88%vs.19.51%,P<0.05).Conclusion Laparoscopy combined with GnRH-a in the treatment of endometriosis with infertility is not only effective,but also can improve the pregnancy rate,which is suitable for promotion.