N-乙酰半胱氨酸雾化吸入治疗老年人社区获得性肺炎的临床疗效

Clinical Experience of N-acetylcysteine Aerosol Inhalation in the Treatment of Elderly Patients with Community-acquired Pneumonia

目的:探讨N-乙酰半胱氨酸雾化吸入治疗老年人社区获得性肺炎(CAP)的临床疗效。方法:将104例老年人CAP患者随机分为观察组和对照组各52例,对照组单纯予抗生素治疗,观察组在对照组的基础上加用N-乙酰半胱氨酸(NAC)溶液0.3 g,氧气驱动雾化吸入,疗程14-21 d,比较两组治疗后临床症状的变化情况及疗效。结果:观察组用药后平均临床症状缓解时间、有效率及细菌清除率均明显优于对照组(P均<0.05);观察组治疗后炎性细胞因子水平均明显低于对照组(P均<0.05)。结论:在使用抗生素的基础上加用NAC雾化吸入治疗老年人CAP能快速改善临床症状,不良反应轻。

Objective:To explore the clinical effect of atomized inhalation of N-acetylcysteine in the treatment of elderly patients with community acquired pneumonia(CAP). Methods:104 elderly patients with CAP were randomly divided into the observation group and the control group,each group was 52 cases. The control group was treated with antibiotics only. The observation group was treated with 0.3g of N-acetylcysteine solution and inhaled with atomization driven by bid oxygen on the basis of the control group. The course of treatment of the two groups was 14-21 days. The changes of clinical symptoms and clinical effects were compared between the two groups after treatment. Results:The average clinical symptom remission time,the effective rate and the bacterial clearance rate in the observation group were significantly better than those in the control group,all P<0.05. The levels of inflammatory cytokines in the observation group were significantly lower than those in the control group,all P<0.05. Conclusion:It can improve clinical symptoms quickly and letter adverse reactions on elderly patients with CAP treated by N-acetylcysteine aerosol inhalation in the basic treatment of antibiotics.