摘要
中性粒细胞胞外诱捕网(NETs)是由多种蛋白质和DNA组成的复杂网状结构。许多研究表明,NETs是机体多种免疫炎性疾病、血栓、癌症等病理生理过程的重要参与者。每个阶段NETs的动态变化可在一定程度上预示病程发展方向。该文就目前有效定量NETs的检测方法进行系统综述,旨为临床慢性炎症和癌症早期检测,以及靶向治疗提供最新的理论参考。
Neutrophil extracellular trap nets(NETs)are complex networks of proteins and DNA.Many studies have shown that NETs are important participants in the pathophysiological processes of various immune inflammatory diseases,thrombosis,cancer and so on.The dynamic changes of NETs at each stage can predict the course of the disease to a certain extent.This article systematically reviews the current detection methods for effectively quantifying NETs in order to provide the latest theoretical reference for the early detection of chronic inflammation and targeted therapy of cancer.
作者
王玉婷
顾兵
李华南
余兆仲
WANG Yu-ting;GU Bing;LI Hua-nan;YU Zhao-zhong(College of Pharmacy,Jiangxi Science&Technology Normal University,Nanchang 330013,China;the Third Dept of Orthopedics and Traumatology,the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第12期1646-1649,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81860857)
国家中医药管理局第四批全国中医(临床、基础)优秀人才研修项目【国中医药人教发(2017)24号】
江西省卫生和计划生育委员会中医药科研基金项目(No 2016A077,2017Z010)
