热休克蛋白27与相关肠道疾病关系的研究进展

Research progress of the relationship between heat shock protein 27 and related intestinal diseases

热休克蛋白(HSP)是一类对细胞有保护作用,能提升机体对外界应激抵抗能力的高度保守蛋白质。热休克蛋白27(HSP27)又称热休克蛋白B1(HSPB1),是一种在人体内由HSPB1基因编码的小分子量HSP。HSP27主要以其磷酸化的活性形式发挥效应,具有伴侣活性、耐热性、抗氧化、抑制细胞凋亡等多种重要生物学功能。HSP27被发现在多种肠道疾病中表达水平升高。该文就HSP27的结构、功能、作用机制及其与相关肠道疾病的关系进行综述,以探究HSP27在肠道疾病的临床应用价值和应用前景。

Heat shock proteins(HSP) are highly conserved proteins that protect cells and enhance the body ’s resistance to stress. Heat shock protein 27(HSP27) also known as heat shock protein beta-1(HSPB1) is a small molecular weight HSP that in humans is encoded by the HSPB1 gene. HSP27 exerts its effect mainly in the form of phosphorylation activity, and has a variety of important biological functions, such as chaperone activity, thermotolerance, anti-oxidation and inhibition of apoptosis. HSP27 was found to be highly expressed in a variety of intestinal diseases. This article reviews the structure, function, mechanism of action of HSP27 and the relationship between HSP27 and intestinal diseases, and explores the clinical value and application prospect of HSP27 in intestinal diseases.