脐血维生素D水平与婴儿反复呼吸道感染的相关性分析

Correlation between cord blood vitamin D level and recurrent respiratory tract infection in infants

目的探讨脐血维生素D水平与婴儿反复呼吸道感染的相关性.方法选择嘉兴市第二医院2014年8月至2015年7月出生的新生儿298例为观察对象,采用酶联免疫法测定新生儿脐血的血清25-羟维生素D[25(OH)D]水平,跟踪随访被测定新生儿的婴儿期呼吸道感染发病情况.结果53.1%(158/298)新生儿维生素D缺乏(缺乏组),24.8%(74/298)新生儿维生素D不足(不足组),22.1%(66/298)新生儿维生素D充足(充足组);维生素D缺乏组、不足组、充足组反复呼吸道感染发生率分别为29.7%(47/158)、17.6%(13/74)、10.6%(7/66),三组反复呼吸道感染发生率差异有统计学意义(χ^2=11.114,P=0.01).结论新生儿维生素D水平与其婴儿期呼吸道感染尤其是下呼吸道感染具有显著的相关性,因此需重视孕期维生素D的补充及检测,以期能降低婴儿呼吸道疾病发生率.

Objective To investigate the correlation between cord blood vitamin D level and recurrent respiratory tract infection in infants.Methods From August 2014 to July 2015,298 neonates in the Second Hospital of Jiaxing were selected in this study.The serum levels of 25-hydroxyvitamin D[25(OH)D]were measured by enzyme-linked immunosorbent assay(ELISA)in umbilical cord blood of neonates.The incidence of respiratory tract infection in infants was followed up.Results There were 53.1%(158/298)newborns with vitamin D deficiency(deficiency group),24.8%(74/298)neonates with inadequate vitamin D(inadequate group),22.1%(66/298)infants with adequate vitamin D(adequate group).The incidence rates of recurrent respiratory infections in vitamin D deficiency group,inadequate group and adequate group were 29.7%(47/158),17.6%(13/74),10.6%(7/66),respectively.The incidence of recurrent respiratory tract infection among the three groups was statistically significantly different(χ^2=11.114,P=0.01).Conclusion Vitamin D nutrition level of neonates has a significant correlation with infants with respiratory tract infection,especially lower respiratory tract infection.Therefore,it is necessary to pay attention to the supplement and detection of vitamin D during pregnancy,so as to reduce the incidence of infant respiratory diseases in the region.