四个基于酰腙配体的双核苄基锡配合物的合成、晶体结构及体外抗癌活性

Syntheses, Crystal Structures and in Vitro Anticancer Activity of Four Binuclear Benzyltin Complexes Based on Acylhydrazone Ligand

通过微波“一锅法”合成了4个双核苄基锡配合物:{[C4H3S(O)C=N-N=C(Me)COO](PhCH2)2Sn(MeOH)}2(C1)、{[C4H3S(O)C=N-N=C(Me)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2(C2)、{[C4H3S(O)C=N-N=C(PhCH2)COO](PhCH2)2Sn(MeOH)}2(C3)、{[C4H3S(O)C=N-N=C(PhCH2)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2(C4),利用元素分析、IR、1H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。4个配合物分子均为双锡核分子,以Sn2O2四元环为中心对称,且中心锡原子与配位原子形成七配位畸变五角双锥构型。测试了配合物C1~C4的热稳定性以及配合物对癌细胞H460、HepG2、MCF7的体外抑制活性,结果表明:配合物C2是4个新合成的配合物中抑制癌细胞效果最好的化合物。

Four dinuclear benzyltin complexes were synthesized by microwave“one-pot synthesis”,namely{[C4H3S(O)C=N-N=C(Me)COO](PhCH2)2Sn(MeOH)}2(C1),{[C4H3S(O)C=N-N=C(Me)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2(C2),{[C4H3S(O)C=N-N=C(PhCH2)COO](PhCH2)2Sn(MeOH)}2(C3),{[C4H3S(O)C=N-N=C(PhCH2)COO](p-Cl-C6H4CH2)2Sn(MeOH)}2(C4).The complexes C1~C4 were characterized by IR,1H NMR,13C NMR 119Sn NMR spectra,elemental analysis,HRMS and the crystal structures were determined by X-ray diffraction.The four complexes are all binuclear molecules,and there was a Sn2O2 four-membered ring in the middle of the molecule.The central tin atom and the coordinating atom form a seven-coordinated pentagonal bipyramid configuration.The thermogravimetric of the complexes C1~C4 were analyzed,and in vitro antitumor activities of the complexes were evaluated by MTT against three human cancer cell lines(H460,HepG2,MCF7).The results show that complex C2 is the best compound for inhibiting cancer cells in the four synthesized complexes.CCDC:1923380,C1;1923381,C2;1923382,C3;1923383,C4.