宣肺平喘方治疗慢阻肺急性加重期痰湿阻肺证患者的临床疗效观察

Clinical effect on chronic obstructive pulmonary disease( phlegm damp blocking the lung) treated with xuanfei pingchuan formula

目的观察宣肺平喘方对慢阻肺急性加重期(痰湿阻肺证)患者的疗效及血清炎性因子的影响。方法纳入2015年1月至2018年1月慢阻肺急性加重期(痰湿阻肺证)患者86例,随机分为治疗组和对照组,治疗组43例,对照组43例,对照组常规抗炎止咳化痰解痉平喘治疗;治疗组在对照组基础上给予宣肺平喘方治疗,连续治疗7 d,观察两组治疗前后咳喘缓解率、中医证候量表评分、肺功能(FEV1及FVC、PEF)、肺功能分级、KPS生活质量评分、CAT评分、C反应蛋白(CRP)、血清炎性因子(IL-6、IL-8)、不良反应等。结果两组治疗后治疗组咳嗽总缓解率为86.1%,对照组总缓解率为72.1%,两组咳嗽总缓解率比较差异有统计学意义(P<0.05)。两组治疗后肺功能FEV1及FVC用力肺活量、PEF呼气峰流速水平明显改善,与治疗前比较差异有统计学意义(P<0.01);且治疗组与对照组比较,差异有统计学意义(P<0.05)。两组治疗后中医证候量表评分、KPS评分、CAT评分,与治疗前比较差异有统计学意义(P<0.01);且治疗组与对照组比较差异有统计学意义(P<0.05)。两组治疗后血清炎性因子(IL-6、IL-8)、CRP与治疗前比较差异有统计学意义(P<0.01);且治疗组与对照组比较差异有统计学意义(P<0.05)。结论宣肺平喘方治疗慢阻肺急性加重期(痰湿阻肺证)患者比单纯西医治疗效果显著,值得临床应用推广。

Objective To observe the effect on chronic obstructive pulmonary disease(phlegm damp blocking the lung)treated with xuanfei pingchuan formula and the impacts of serum inflammatory factors.Methods From January 2015 to January 2018,86 patients with chronic obstructive pulmonary disease(phlegm damp blocking the lung)were randomized into a treatment group and a control group,43 cases in each one.In the control group,the routine treatment was used for anti-inflammation,stopping cough,resolving phlegm and relieving asthma.In the treatment group,on the base of the treatment as the control group,xuanfei pingchuan formula was added.The treatment was given consecutively for 7 days.Before and after treatment,the cough and asthma remission rate,TCM symptom score,lung functions(FEV1,FVC and PEF),lung function grade,KPS life quality score,CAT score,CRP,serum inflammatory factors(IL-6 and IL-8)and adverse reactions were observed in the two groups.Results After treatment,the total remission rate was 86.1%in the treatment group and was 72.1%in the control group,indicating the statistical significance(P<0.05).After treatment,FEV1,FVC and PEF were improved obviously as compared with those before treatment in the two groups(P<0.01)and the results in the treatment group were different significantly than the control group(P<0.05).After treatment,TCM symptom score,KPS score and CAT score were different significantly as compared with those before treatment in the two groups(P<0.01)and the results in the treatment group were different significantly as compared with the control group(P<0.05).After treatment,the levels of serum inflammatory factors(IL-6 and IL-8)and CRP were different significantly as compared with those before treatment in the two groups(P<0.01)and the levels in the treatment group were different statistically as compared with the control group(P<0.05).Conclusion Xuanfei pingchuan formula achieves the significant effect on chronic obstructive pulmonary disease(phlegm damp blocking the lung)as compared with simple western medicine.Hence,this therapy deserves to be promoted in clinical practice.