能量代谢在癫痫疾病中的研究进展

Research progress on energy metabolism in epilepsy

大脑是高耗能器官,需要消耗大量能量才能发挥其功能,能量代谢对维持正常的神经功能起重要作用。近年来多项研究显示,在癫痫发作过程中大脑存在异常能量代谢,星形胶质细胞在能量平衡控制中起重要作用。生酮饮食疗法是目前疗效较好的代谢相关治疗方法,用于治疗难治性癫痫的效果较好。该文就能量代谢在癫痫疾病中的研究进展作一综述。

The brain is a high energy-consuming organ.It requires a large quantity of energy to perform its function.Energy metabolism plays a pivotal role in maintaining normal nerve function.In recent years,multiple studies have demonstrated that abnormal energy metabolism of the brain occurs during the onset of epilepsy.Astrocytes play an important role in controlling energy balance.Ketogenic diet(KD)is a relatively efficacious metabolic treatment of refractory epilepsy.In this article,the research progress on energy metabolism in epilepsy was reviewed.