维生素D缺乏在慢性HBV感染中的研究进展

Research progress on vitamin D deficiency in chronic HBV infection

维生素D缺乏是指血清25-羟维生素D3水平低于20 ng/ml(50 nmol/L)。已有的研究证实维生素D缺乏在慢性丙型肝炎及非酒精性脂肪性肝病等慢性肝病中广泛存在,这在临床习惯建议多休息和清淡饮食的慢性HBV感染人群中其发病可能更为普遍,但系统研究缺乏。鉴于此,近年来开始涌现了聚焦维生素D缺乏在慢性HBV感染者中的发病率及影响因素的多项研究,包括流行病学研究和实验性研究,旨在探究其发病的普遍性及开展治疗干预的合理性。该文结合维生素D缺乏在慢性HBV感染人群中的研究进展,对维生素D缺乏在此类患者中的检出率及其与病毒载量和疾病进展的相关性进行综述。

Vitamin D deficiency is defined as the serum level of 25(OH)D3 is lower than 20 ng/ml(50 nmol/L).Previous studies have confirmed that Vitamin D deficiency widely exists in chronic liver diseases,such as chronic hepatitis C and nonalcoholic fatty liver disease.It is probably more common in chronic hepatitis B virus(HBV)infection patients who are usually advised to have a good rest and light diet.Unfortunately,systematic study is still lacking.Consequently,multiple studies focusing on the prevalence and influencing factors of Vitamin D deficiency in patients with chronic HBV infection have been conducted in recent years,including epidemiological and experimental studies,aiming to investigate the prevalence of Vitamin D deficiency and the rationality of treatment intervention.In this article,research progress on Vitamin D deficiency in chronic HBV infection was reviewed,aiming to investigate the detection rate of Vitamin D deficiency and its correlation with viral load and disease progression.