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比较度洛西汀和氟哌噻吨美利曲辛片治疗抑郁症伴躯体疼痛障碍的临床疗效 被引量:7

Comparison on clinical efficacy of duloxetine and flupentixol/melitracen in the treatment of depression with somatoform pain disorder
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摘要 目的分析比较度洛西汀和氟哌噻吨美利曲辛片治疗抑郁症伴躯体疼痛障碍的临床疗效。方法 94例抑郁症伴躯体疼痛障碍患者,按照随机数字表法随机分为参照组和研究组,各47例。参照组给予氟哌噻吨美利曲辛片治疗,研究组给予度洛西汀治疗。比较两组的治疗效果及疼痛分级指数(PRI)评分、视觉模拟评分法(VAS)评分、现时疼痛强度(PPI)评分。结果研究组的治疗有效率97.87%高于参照组的82.98%,差异有统计学意义(P<0.05)。研究组的PRI评分(6.23±1.69)分、VAS评分(2.91±1.01)分和PPI评分(2.19±0.92)分均低于参照组的(10.72±1.62)、(6.34±0.91)、(3.73±0.83)分,差异均有统计学意义(P<0.05)。结论在抑郁症伴躯体疼痛障碍的治疗工作中应用度洛西汀能起到更好的治疗效果,止痛作用更快,具有推广价值。 Objective To analyze and compare the clinical efficacy of duloxetine and flupentixol/melitracen in the treatment of depression with somatoform pain disorder. Methods A total of 94 cases of depression with somatoform pain disorder were divided into control group and research group by random number table method, with 47 cases in each group. The control group was treated with flupentixol/melitracen, and the research group was treated with duloxetine. Comparison was made on therapeutic effect, pain rating index(PRI), visual analogue scale(VAS) score and present pain intensity(PPI) score between the two groups. Results The total effective rate of treatment was 97.87% in the research group, which was higher than 82.98% in the control group, and the difference was statistically significant(P<0.05). The PRI score, VAS score and PPI score were(6.23±1.69),(2.91±1.01) and(2.19±0.92) points in the research group, which was lower than(10.72±1.62),(6.34±0.91) and(3.73±0.83) points in the control group, and their difference was statistically significant(P<0.05). Conclusion Duloxetine shows better therapeutic effect and a faster analgesic effect in the treatment of depression with physical pain disorder, and it contains promotional value.
作者 左进涛 ZUO Jin-tao(Dalian Fifth People’s Hospital,Dalian 116023,China)
出处 《中国现代药物应用》 2019年第23期117-118,共2页 Chinese Journal of Modern Drug Application
关键词 度洛西汀 氟哌噻吨美利曲辛 抑郁症伴躯体疼痛障碍 Duloxetine Flupentixol/melitracen Depression with somatoform pain disorder
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