定痫丸对风痰闭阻型耐药性癫痫患者血清炎症因子-铁代谢途径的影响

Effect of Dingxiam Pill on Inflammatory Factor-Iron Metabolism Pathway in Patients with DRE of Wind and Phlegm obstruction

目的:观察定痫丸对风痰闭阻型耐药性癫痫患者的临床疗效,并探讨其对炎症因子-铁代谢途径的作用。方法:将64例风痰闭阻证耐药性癫痫患者随机分成观察组和对照组,每组32例。观察组在原有抗癫痫药物的基础上给予中药定痫丸治疗,对照组为单纯使用抗癫痫药物治疗;对比治疗后3个月和6个月的临床疗效,并观察治疗前、疗后3个月及6个月的血清炎症因子(TNF-α、IL-1β、IL-6、IL-10)及铁代谢(血清铁、总铁结合力、铁蛋白)水平的变化。结果:①观察组经定痫丸联合抗癫痫西药治疗后3个月、6个月与治疗前3个月相比,癫痫发作频次明显减少、持续时间亦明显缩短(P均<0.05),与对照组具有明显差异(P<0.05);治疗后3个月、6个月观察组总有效率均高于对照组(P<0.05)。②治疗后3个月和6个月观察组血清IL-1β、IL-6和TNF-α水平均下降(P<0.05),与对照组相比有明显差异(P<0.05)。③观察治疗后3个月、6个月血清铁含量增加(P<0.05),总铁结合力和铁蛋白水平下降(P<0.05),与对照组相比具有明显差异(P<0.05)。结论:定痫丸联合抗癫痫西药治疗风痰闭阻型耐药性癫痫,可减少患者癫痫发作次数及持续时间,减轻临床症状,降低炎症因子水平,调节铁代谢途径,从而减轻患者神经炎症反应,提高临床疗效。

Objective:To observe the clinical effect of Dingxian Pill in the treatment of drug-resistant epilepsy(DRE)of wind and phlegm obstruction,and to explore its effect on inflammatory factor-iron metabolism pathway.Methods:64 patients with DRE were randomly divided into the control group(n=32)and the observation group(n=32).The control group was treated with antiepileptics;on which basis,the observation group was also treated with Dingxian Pill.Clinical efficacy was compared after 3 months and after 6 months of treatment,and changes of serum inflammatory factors(TNF-α,IL-1β,IL-6 and IL-10)and iron metabolism(serum iron,total iron binding capacity and ferritin)were observed before the treatment,after 3 months of treatment and after 6 months of treatment.Results:The frequency and duration of epileptic seizures were significantly reduced after 3 months and after 6 months of treatment in the observation group(P<0.05);of which the differences between the two groups were significant.The total effective rates of the observation group were higher than those of the control group after 3 months and after 6 months of treatment(P<0.05);of which the differences were significant between the observation group and the control group(P<0.05).Serum levels of IL-1β,IL-6 and TNF-αwere decreased after 3 months and 6 months of treatment in the observation group(P<0.05);of which there were statistical difference between the observation group and the control group(P<0.05).Serum level of iron was increased(P<0.05),and total iron binding capacity and ferritin were decreased(P<0.05)after 3 months and 6 months of treatment;there were statistical differences when compared to the control group(P<0.05).Conclusion:Dingxian Pill combined with antiepileptics can reduce the frequency and the duration of seizures in patients with drug-resistant epilepsy of wind and phlegm obstruction,it can alleviate clinical symptoms and reduce the level of inflammatory factors,regulate the iron metabolism pathway,so as to reduce the neuroinflammatory response and improve the clinical effect.