补肺活血胶囊联合汉防己甲素片治疗煤工尘肺病人疗效观察

Observation on treating coal worker’s pneumoconiosis with the Bufei Huoxue capsule plus tetrandrine tablets

目的:研究补肺活血胶囊联合汉防己甲素片治疗煤工尘肺(Coal Worker’s Pneumoconiosis,CWP)病人的疗效。方法:收集2016年2月-2017年9月本院治疗的76例煤工尘肺病人,分为对照组(予以常规平喘、祛痰、止咳、抗炎治疗)与研究组(予以常规治疗基础上给予补肺活血胶囊与汉防己甲素片治疗),每组38例。通过比较两组治疗后血气指标[血氧分压(Partial Pressure of Oxygen,PaO2),血二氧化碳分压(Partial Pressure of Carbon Dioxide,PaCO2),血氧饱和度(Oxygen Saturation,SaO2)]、肺功能指标[1s用力呼气肺容积(Forced Expiratory Volume in 1 second,FEV1),肺活量(Vital Capacity,VC),第一秒用力呼气量占所有呼气量的比例(FEV1/FVC)]、免疫球蛋白G(Immunoglobulin G,IgG)、C反应蛋白(C-reactive Protein,CRP)、肿瘤坏死因子-α(Tumor Necrosis Factor,TNF-α)水平评价治疗效果。结果:治疗后,研究组血气指标PaO2、PaCO2、SaO2改善程度均明显优于对照组;肺功能指标FEV1、VC、FEV1/FVC水平均明显高于对照组;CRP、TNF-α、IgG指标水平均明显低于对照组;差异均有统计学意义(P<0.05)。结论:补肺活血胶囊联合汉防己甲素片治疗煤工尘肺病人疗效显著,能够显著改善患者血气分析与肺功能,降低炎症反应,提高机体免疫功能。

Objective: To study efficacy of the Bufei Huoxue capsule( 补肺活血胶囊) plus Tetrandrine tablets on coal worker’s pneumoconiosis. Methods: 76 cases were divided into two groups, 38 cases in each. The control group was given conventional treatment, and the study group was given the Bufei Huoxue capsule plus tetrandrine tablets more. Results: In the study group, PaO2, PaCO2 and SaO2, FEV1, VC, FEV1/FVC levels were significantly better. The levels of CRP, TNF-α and IgG were significantly lower than those in the control group(P<0.05). Conclusion: The Bufei Huoxue capsule plus tetrandrine tablets on coal worker’s pneumoconiosis shows good effects, can significantly improve blood gas indes, lung function and immune function, and reduce inflammation.