徐斌治疗乳腺癌术后用药规律的数据挖掘分析

A data analysis of postoperative medication in treating breast cancer by Xu Bin

目的:初步探讨徐斌教授治疗乳腺癌术后患者的处方用药规律。方法:收集就诊于徐斌教授门诊的乳腺癌术后195患者的首诊病案信息,建立临床信息资料库,运用SPSS 19.0软件对患者的基本情况、证型、处方用药进行频数分析,对常用中药进行聚类分析。结果:本研究共收集于徐斌教授门诊就诊的195例乳腺癌术后患者,在中医处方用药方面,分析结果显示:(1)使用频次最高的前10味药物依次为川芎、郁金、半夏、生黄芪、姜黄、白芍、猫爪草、枳壳、鸡内金、当归。(2)将药物频数≥24次的药物按功效归类和整理,使用频率依此为疏肝理气药和活血化瘀药,其次为健脾益气、化瘀散结、清热解毒等。(3)中药聚类分析:得出以下6组药物群:郁金、姜黄、川芎,香附、柴胡、白芍,连翘、白花蛇舌草、黄芩、猫爪草,枳壳、炒莱菔子、鸡内金,远志、炒酸枣仁、白术、茯苓,生黄芪、当归、生地黄、杜仲。药对:郁金+姜黄、香附+柴胡、连翘+白花蛇舌草、枳壳+莱菔子、远志+酸枣仁、白术+茯苓、生黄芪+当归。结论:徐斌教授认为肝郁脾虚是乳腺癌的基本病机,治疗乳腺癌术后特色有四方面:①肝脾同治、抑木培土;②气血同治、气通血活;③肝肾同治、以资化源,④善用药对,减毒增效。

Objective: To investigate postoperative medication in treating breast cancer by Xu Bin. Methods: Information at first time in 195 patients who were treated in the Xu Bin’s outpatient clinic was collected, and a clinical information database was established. The patient’s basic condition, syndromes and prescription medication were analyzed by SPSS 19.0 software. TCM medicine was analyzed by cluster analysis. Results: The top 10 medicine with the highest frequency were Chuanxiong( 川芎), Yujin( 郁金), and Banxia( 半夏), Shenghuangqi(生黄芪), Jianghuang(姜黄), Baishao(白芍), Maozhuacao(猫爪草), Zhike(枳壳), Ji’neijin(鸡内金), Danggui(当归). The medicine applied more than 24 times are classified and sorted according to their efficacy. The application of medicine is mainly Shugan Liqi( 疏肝理气) medicine and Huoxue Huayu( 活血化瘀) medicine, followed by Jianpi Yiqi( 健脾益气), Huayu Sanjie( 化瘀散结), Qingre Jiedu( 清热解毒), etc.. 6 groups of medicine were found by cluster analysis. Conclusion: Professor Xu Bin believes that Ganyu Pixu( 肝郁脾虚) is the basic pathogenesis of breast cancer. 4 aspects of postoperative treatment of breast cancer were reviewed.