加味四君子汤治疗腹泻型肠易激综合征的临床疗效观察

Effective observation on treating diarrhea-type irritable bowel syndrome with the Sijunzi decoction

目的:研究加味四君子汤运用于腹泻型肠易激综合征中的价值。方法:选择我院2017年6月-2018年8月纳入的106例腹泻型肠易激综合征患者,按照数字表法随机分为两组,各53例,研究组采取加味四君子汤,对照组采取常规治疗,对比两组治疗结果。结果:研究组总有效率(92.45%)高于对照组的81.13%(P <0.05);治疗前两组腹痛、腹泻、食少纳差及腹胀肠鸣评分无差异(P> 0.05),治疗后研究组各评分均低于对照组(P <0.05);治疗前两组的肿瘤坏死因子-α(Tumor Necrosis Factor,TNF-α)、白细胞介素(Interleukin,IL)-6水平无差异(P> 0.05),治疗后研究组TNF-α、IL-6均低于对照组(P <0.05)。治疗前两组的5-羟色胺(5-Hydroxytryptamine,5-HT)3、5-HT4受体mRNA水平相比无差异(P> 0.05),治疗后5-HT3、5-HT4受体m RNA水平均低于对照组(P <0.05)。结论:加味四君子汤运用于腹泻型肠易激综合征中效果明显,促进相关症状消退,改善病情,减轻炎症,为预后提供保障。

Objective: To study efficacy of the Sijunzi decoction( 加 味 四 君 子 汤) on diarrhea-type irritable bowel syndrome. Methods: 106 cases were divided into two groups, 53 cases in each. The control group was given conventional treatment;and the study group was given the Sijunzi decoction. Results: The total efficiency was 92.45% in the study group, higher than 81.13% in the control group, P<0.05. After treatment, the clinical symptom scores were lower in the study group(P<0.05). The levels of TNF-α, IL-6, mRNA levels of 5-HT3 and 5-HT4 in the study group were lower(P<0.05). Conclusion: The Sijunzi decoction on diarrhea-type irritable bowel syndrome shows good effects, can improve clinical symptoms and condition, reduce inflammation, and provide protection for the prognosis.