姑息性干预对晚期恶性肿瘤患者生活质量及癌因性疲乏的影响

The effect of palliative intervention on the quality of life and cancer-related fatigue in patients with advanced malignant tumor

目的探讨姑息性干预对晚期恶性肿瘤患者生活质量及癌因性疲乏的影响。方法根据随机数字表法将68例晚期恶性肿瘤患者分为对照组(接受常规干预)和研究组(接受姑息性干预),每组34例。干预前和干预4周后,采用癌症治疗功能评价(FACT-G)量表比较两组患者的生活质量,采用症状自评量表(SCL-90)比较两组患者的心理状态,采用癌症疲乏量表(CFS)比较两组患者的癌因性疲乏程度。结果干预4周后,研究组患者FACT-G量表的功能、情感、生理和社会/家庭各维度评分均高于对照组患者,SCL-90量表恐怖、敌对、焦虑、人际关系、强迫症状、抑郁、躯体化、偏执和精神病性因子评分均低于对照组患者,差异均有统计学意义(P﹤0.05)。干预4周后,研究组患者CFS量表的认知、情感、躯体疲乏评分及总分均明显低于对照组患者,差异均有统计学意义(P﹤0.01)。结论姑息性干预可明显提高晚期恶性肿瘤患者的生活质量,改善患者的心理状态,减轻患者的癌因性疲乏程度。

Objective To investigate the effect of palliative intervention on the quality of life and cancer-related fatigue in patients with advanced malignant tumor. Method A total of 68 patients with advanced malignant tumor were included in the study as control group(conventional intervention) or study group(palliative intervention), each with 34 cases. Before and 4 weeks after intervention, quality of life was compared between the two groups using the functional assessment of cancer therapy-general(FACT-G) scale, psychological status was compared between the two groups using the symptom checklist-90(SCL-90), and cancer fatigue scale(CFS) was was used to compare the degree of cancer induced fatigue between the two groups. Result After 4 weeks of intervention, the scores of functional, emotional, physiological and social/family dimension of the FACT-G scale in the study group were significantly higher than those in the control group, the scores in regard to fear, hostility, anxiety, interpersonal relationship, obsessive-compulsive symptoms, depression, somatization, paranoia ideation and psychoticism of the SCL-90 scale in study group were significantly lower compared to control group, the differences were statistically significant(P<0.05). After 4 weeks of intervention, the scores of cognitive, emotional, and physical fatigue as well as overall score of the CFS scale in study group were significantly lower than those in the control group(P<0.01). Conclusion Compared with conventional intervention, palliative management significantly improves the quality of life of patients with advanced malignant tumor, reducing cancer-related fatigue, and improving the psychological status of patients.