HP感染伴肠道菌群失调对结直肠癌发病的相关性分析

An Analysis on the Relativity of Colorectal Cancer Pathogenesis with Helicobacter Pylori Infection Associated with Dysbacteriosis of Intestinal Tract

为分析HP感染伴肠道菌群失调对结直肠癌发病的相关性及影响因素,选取我院结直肠癌患者120例,统计本组患者术前HP感染、肠道菌群失调及HP感染伴肠道菌群失调情况,计算发生率。分析HP感染伴肠道菌群失调对结直肠癌发病的相关性及危险因素。结果显示,120例结直肠癌患者中发生HP感染伴肠道菌群失调98例,发生率81.67%。其中单HP感染98例,感染率81.67%;单肠道菌群失调101例,失调率84.17%。结直肠癌HP感染伴肠道菌群失调与年龄、性别无相关性(P>0.05),与肿瘤部位、分化程度、肿瘤大小、病理分期、淋巴结转移、服药史明显相关(P<0.05),其中服药史是结直肠癌患者HP感染伴肠道菌群失调独立危险因素(P<0.05)。结果表明,HP感染伴肠道菌群失调能增加结直肠癌发病风险,服药史是HP感染伴肠道菌群失调患者结直肠癌发生的独立危险因素。临床应积极干预此类患者,减少结直肠癌发生风险。

This study was to analyse the relativity of colorectal cancer pathogenesis with helicobacter pylori(HP)infection associated with intestinal tract dysbacteriosis(ITD),and to investigate its relevant influence factors,enrolled 120 patients with colorectal cancer treated in author’s hospital into this study:according to preoperative HPinfection,ITD,and HPinfection complicated with ITD,etc status,estimated incidence,further analysed above mentioned relativity and risk factors.As results,in 120 cases,both associated patients were in 98(81.67%),among them,alone HPinfection in 98 cases(81.67%),alone dysbacteriosis in101 cases(84.17%);both associated did not related to age,gender(P>0.05),but were related to tumor site,differentiation degree,size,pathological stage,lymphnode metastasis and medication history closely(P<0.05),especially,medication history was an independent risk factor(P<0.05).Results show that both associated emergency can increase pathogenesis risk of colorectal cancer,in particular,medication history is an independent risk factor,therefore,clinically such patients should be actively intervened,so as to reduce pathogenesis risk.