消痔灵注射液联合地奥司明治疗内痔51例疗效观察

Observation on the Effect of Xiaozhiling Injection Combined with Diosmin in the Treatment of 51 Cases of Internal Hemorrhoids

为观察消痔灵注射液联合地奥司明治疗内痔的疗效,将102例内痔患者随机分为对照组和观察组,每组51例。对照组患者采用消痔灵注射液治疗,观察组在对照组治疗的基础上口服地奥司明片治疗,比较2组患者的疗效、疼痛程度及炎症因子情况。结果显示,观察组患者总有效率为82.4%,对照组60.8%,2组比较差异有统计学意义(P<0.05)。观察组患者0级、Ⅰ级疼痛发生率均高于对照组(P<0.05),Ⅱ、Ⅲ级疼痛发生率均低于对照组(P<0.05)。治疗后2组患者TNF-α、IL-1β、IL-6、IL-8水平均低于治疗前,但观察组明显低于对照组(P<0.05)。结果表明,消痔灵注射液联合地奥司明可有效治疗内痔,缓解患者疼痛症状,降低炎症因子水平,有助于患者恢复。

In order to observe the curative effect of Xiaozhiling injection combined with Diosmin in the treatment of internal hemorrhoids(IH),102 patients with IH were randomly divided into control group(n =51,received Xiaozhiling injection)and observation group(n =51,received Diosmin tablets on the basis of the control group).The curative effect,pain degree and inflammatory factors of the two groups were compared.As results,the total effective rate was 82.4%in the observation group and 60.8%in the control group,there was statistical difference between the two groups(P<0.05).The incidence of grade 0 and gradeⅠpain in the observation group was higher than that in the control group(P<0.05),and the incidence of grade II and gradeⅢ pain in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of TNF-α,IL-1β,IL-6,IL-8 in the two groups were lower than those before treatment,but the observation group was significantly lower than the control group(P<0.05).The results show that Xiaozhiling injection combined with Diosmin can effectively treat IH,relieve pain symptoms and reduce the level of inflammatory factors,which is helpful to the recovery of internal hemorrhoids.