调节性T细胞分化和功能调节机制的研究进展

Advances in the regulatory mechanism of differentiation and function in regulatory T cells

调节性T(Treg)细胞对于维持免疫稳态和耐受性是必需的,随着Treg细胞在自身免疫性疾病及肿瘤方面的深入研究,我们发现Treg细胞靶向治疗已成为一种新的治疗措施。但目前Treg细胞稳定性和功能方面的调节机制尚未完全阐明。而在成熟Treg细胞中FOXP3的靶向缺失不会干扰Treg细胞的关键特性,例如其无应答表型和Treg标记物(例如CD25,CTLA-4和Helios)的表达。提示我们Treg细胞的特性和功能存在其他的信号分子来调节,本综述将阐述调节Treg分化及功能调节机制的研究进展。

Regulatory T(Treg) cells are essential for maintaining immune homeostasis and tolerance. With the in-depth study of Treg cells in autoimmune diseases and tumors, we have found that Treg cell-targeted therapy has become a new treatment measures. However, the regulatory mechanisms of Treg cell stability and function have not yet been fully elucidated. Targeted deletion of FOXP3 in mature Treg cells does not interfere with key features of Treg cells, such as its non-responsive phenotype and expression of Treg markers(eg: CD25, CTLA-4 and Helios),suggesting that the characteristics and functions of Treg cells are regulated by other signaling molecules. This review will describe the advances in the regulation of Treg differentiation and function.