9.4 T下TX模型小鼠脑组织的扩散张量成像研究

Diffusion Tensor Imaging on TX Mice Brain at 9.4 T

本文首次应用9.4T高场磁共振扩散张量成像(diffusion tensor imaging,DTI)技术,研究了Wilson疾病模型TX(toxic milk)小鼠的脑组织微观结构改变和结构连接情况.基于感兴趣区域(region of interest,ROI)的分析发现,与对照组相比,TX模型组的各向异性比值(fractional anisotropy,FA)在海马、尾状核和苍白球显著下降;平均扩散率(mean diffusivity,MD)则呈现上升趋势,但无统计学意义.纤维束追踪法结果表明TX模型组小鼠的脑结构连接并未受到严重破坏,证明了铜累积对脑组织的损伤具有区域性.

Diffusion tensor imaging(DTI)was used to evaluate micro-structural changes and structural connectivity in the TX mice model of Wilson’s disease(WD)at 9.4 T.Region of interest(ROI)analysis showed that mean fractional anisotropy(FA)values in the hippocampus,caudate putamen and lateral globus pallidus of the TX mice decreased significantly,relative to those in the control mice.The mean diffusivity(MD)values in these regions showed no significant inter-group differences.The results of fiber tracking demonstrated that structural connectivity of in the brain of TX mice was maintained,indicating that the effects of copper accumulation in these mice were mainly regional.