无症状原发性甲状旁腺激素亢进临床特点及诊疗措施

Clinical characteristics,diagnosis and treatment measures of asymptomatic primary hyperparathyroidism

原发性甲状旁腺功能亢进症(primary hyperparathyroidism,PHPT)是一种由于甲状旁腺组织原发病变引起甲状旁腺素(parathyroidhormone,PTH)分泌过多,进而导致钙代谢紊乱为主的内分泌系统疾病.近些年随着多种生化筛查的开展,血清钙和血清甲状旁腺素检测率得以升高,PHPT发病率也随之升高,而这其中大部分是无症状患者.目前对于无症状型原发性甲状旁腺激素亢进(asymptomatic primary hyperparathyroidism,aPHPT)的诊治标准仍存在争议,本文根据美国国立卫生院2014年修订的指南,分享最新研究进展,旨在为完善aPHPT患者综合管理和改善aPHPT患者生存质量提供一些建议.

Primary Hyperparathyroidism is a calcium metabolism disorder of endocrine system diseases which caused by hypersecretion of parathyroid hormone by primary lesion of parathyroid tissue.In recent years,with the development of medical diagnostic technology,in particular,the development of a variety of biochemical screening,the incidence of primary hyperparathyroidism also increased and most of these patients are asymptomatic.At present,the diagnosis and treatment standard of asymptomatic primary hyperparathyroidism is still controversial,This article is based on Guidelines for the management of asymptomatic primary hyperparathyroidism in 2014 and sharing the latest research progress to proved some suggestions for improving the medical management of asymptomatic primary hyperparathyroidism patients and improving the quality of life of them.