肠碱性磷酸酶在肠黏膜屏障中的作用

Role of intestinal alkaline phosphatase in intestinal mucosal barrier

肠碱性磷酸酶(intestinal alkaline phosphatase,IAP)是一种碱性磷酸酶,在维持肠黏膜屏障的稳定和肠道功能具有重要作用,其中包括调节十二指肠pH、反映肠道的发育情况及小肠上皮细胞的吸收能力,降低肠道脂多糖毒力、预防和减少肠道炎症、调节肠道菌群分布、抑制细菌位移、改善肠道钙吸收等功能.本文对近年来IAP在肠黏膜屏障中的作用研究进展做一综述.

Intestinal alkaline phosphatase(IAP)is an alkaline phosphatase that plays an important role in maintaining the stability of the bowel function and the intestinal mucosal barrier,including adjusting the duodenal pH,participating the development of the intestinal tract,regulating the absorption ability of intestinal epithelial cells,reducing the toxicity of lipopolysaccharide,preventing and reducing the intestinal inflammation,regulating intestinal flora,improving intestinal calcium absorption,etc.In this paper,we will review the role of IAP in intestinal mucosal barrier.