盐酸坦索罗辛缓释胶囊对输尿管双J管留置患者的临床症状和生活质量影响

Effects of tamsulosin hydrochloride sustained release capsule in improving symptoms and quality of life of patients with indwelling double-J ureteral stents

目的 探讨盐酸坦索罗辛缓释胶囊对输尿管双J管留置患者的临床症状及生活质量的影响.方法 输尿管双J管留置患者96例,随机分为对照组和观察组各48例.对照组术后常规抗感染治疗,观察组在此基础上给予盐酸坦索罗辛缓释胶囊0. 2 mg,每天1次,口服1个月.比较两组术后4周拔管时输尿管相关症状问卷 (USSQ)、国际前列腺症状评分( IPSS)、生活质量评分(QOL)、视觉模拟评分(VAS)、OAB症状评分问卷( OABSS)情况,并记录服药期间药物的不良反应.结果 观察组USSQ量表尿路刺激症状、躯体疼痛、性生活满意度和工作能力评分分别为(25. 23 ± 4. 35)分、(14. 58 ± 2. 84)分、(3. 82 ± 1. 03)分和(12. 83 ± 3. 85)分,低于对照组的(31. 29 ± 4. 48)分、(30. 39 ± 3. 91)分、(5. 83 ± 1. 94)分和(18. 81 ± 5. 03)分,差异均有统计学意义( P<0. 05).观察组IPSS量表储尿期症状和总评分分别为(3. 31 ± 1. 38)分和(6. 87 ± 2. 94)分,低于对照组的(6. 14 ± 2. 03)分和(10. 31 ± 2. 26)分,差异均有统计学意义( P<0. 05).观察组OABSS、VAS和QOL评分分别为(4. 31 ± 1. 28)分、(1. 95 ± 1. 07)分和(1. 54 ± 0. 93)分,低于对照组的(9. 29 ± 2. 87)分、(4. 04 ± 1. 23)分和(3. 24 ± 0. 93)分,差异均有统计学意义(P<0. 05).结论 盐酸坦索罗辛缓释胶囊能够明显改善输尿管双J管留置患者输尿管支架管相关症状和前列腺症状,减轻疼痛,提高患者生活质量.

Objective To investigate the influence of tamsulosin hydrochloride sustained release capsule in improving symptoms and quality of life of patients with indwelling double-J ureteral stents.Methods From March 2016 to June 2017,96 patients with indwelling double-J ureteral catheter were randomly divided into control group and observation group,with 48 patients in each group.The control group did not take drugs after operation,and the patients in the observation group were treated with tamsulosin hydrochloride sustained release capsule once a day,totally for 1 month.All the enrolled patients completed the Ureteral Stent Symptom Questionnaire(USSQ),the International Prostate Symptom Score(IPSS),quality of life(QOL),visual analogue scale(VAS)as well as the Overactive Bladder Symptom Score(OABSS)on the day after the removal of the stent 4 weeks after treatment.Results The mean urinary symptom index score,the pain index score,the sex index score and the ability index of work score of the observation group were(25.23±4.35),(14.58±2.84),(3.82±1.03)and(12.83±3.85),lower than the score(31.29±4.48),(30.39±3.91),(5.83±1.94)and(1&81±5.03)of the control group.The storage stage score and IPSS total score were respectively(3.31±1.38)and(6.87±2.94),lower than the score(6.14±2.03)and(10.31±2.26)of the control group.The QOL,VAS,OABSS score were(1.54±0.93),(1.95±1.07)and(4.31±1.28),lower than the score(3.24±0.93),(4.04±1.23)and(9.29±2.87)of the control group.As opposed to the control group,it was observed that observation group prominently improved and the scores were statistically significant(P<0.05).Conclusions Tamsulosin hydrochloride sustained release capsule can significantly improve the related symptoms of indwelling double-J ureteral stents and prostatic symptoms,reduce pain,improve patients quality of life.