摘要
Neural stem cells(NSC)act as a versatile tool for neuronal cell replacement strategies to treat neurodegenerative disorders in which functional neurorestorative mechanisms are limited.While the beneficial effects of such cellbased therapy have already been documented in terms of neurodegeneration of various origins,a neurophysiological basis for improvement in the recovery of neurological function is still not completely understood.This overview briefly describes the cumulative evidence from electrophysiological studies of NSCderived neurons,aimed at establishing the maturation of differentiated neurons within a host microenvironment,and their integration into the host circuits,with a particular focus on the neurogenesis of NSC grafts within the post-ischemic milieu.Overwhelming evidence demonstrates that the host microenvironment largely regulates the lineage of NSC grafts.This regulatory role,as yet underestimated,raises possibilities for the favoured maturation of a subset of neural phenotypes in order to gain timely remodelling of the impaired brain tissue and amplify the therapeutic effects of NSC-based therapy for recovery of neurological function.
Neural stem cells(NSC) act as a versatile tool for neuronal cell replacement strategies to treat neurodegenerative disorders in which functional neurorestorative mechanisms are limited. While the beneficial effects of such cellbased therapy have already been documented in terms of neurodegeneration of various origins, a neurophysiological basis for improvement in the recovery of neurological function is still not completely understood. This overview briefly describes the cumulative evidence from electrophysiological studies of NSCderived neurons, aimed at establishing the maturation of differentiated neurons within a host microenvironment, and their integration into the host circuits, with a particular focus on the neurogenesis of NSC grafts within the post-ischemic milieu. Overwhelming evidence demonstrates that the host microenvironment largely regulates the lineage of NSC grafts. This regulatory role, as yet underestimated, raises possibilities for the favoured maturation of a subset of neural phenotypes in order to gain timely remodelling of the impaired brain tissue and amplify the therapeutic effects of NSC-based therapy for recovery of neurological function.
