小剂量甲状腺素治疗老年高血压合并心力衰竭疗效观察

Therapeutic effect of low-dose thyroxine on elderly patients with hypertension complicated with heart failure

目的探讨小剂量甲状腺素治疗老年高血压合并心力衰竭患者的临床疗效.方法将80例老年高血压合并心力衰竭患者按随机数字表法分为两组,每组40例.两组均予以常规治疗,研究组在此基础上联合小剂量甲状腺素治疗,观察28 d.比较两组患者临床疗效及治疗前后血清三碘甲状腺原氨酸、总甲状腺素及左心室射血分数水平的变化.结果研究组治疗总有效率为95.0%,对照组为77.5%,研究组显著高于对照组(P<0.05).治疗后研究组血清三碘甲状腺原氨酸、总甲状腺素及左心室射血分数水平均显著高于对照组(P<0.05).结论在常规药物治疗的基础上,联合小剂量甲状腺素治疗老年高血压合并心力衰竭患者疗效显著,值得临床推广.

Objective To explore the clinical effect of low-dose thyroxine in the treatment of elderly hypertension complicated with heart failure.Methods 80 elderly patients with hypertension complicated with heart failure were divided into two groups according to the random number table,with 40 cases in each group.Both groups were given routine treatment,and the study group was given low-dose thyroxine on this basis.The two groups were observed for 28 days.The clinical effect of the two groups and the changes of serum triiodothyronine,total thyroxine and left ventricular ejection fraction(LVEF)before and after treatment were compared.Results The total therapeutic effective rate of the study group was 95.0%,which is significantly higher than that of the control group(77.5%)(P<0.05).The levels of serum triiodothyronine,total thyroxine and LVEF in the study group were significantly higher than those in the control group(P<0.05).Conclusions The conventional drug therapy combined with low-dose thyroxine is therapeutically effective in the treatment for elderly patients with hypertension and heart failure,which is worthy of clinical promotion.