特发性肺纤维化合并肺癌

Idiopathic pulmonary fibrosis and lung cancer

特发性肺纤维化合并肺癌多见于男性、高龄和吸烟者,是一种无特殊临床表现、无明确治疗策略、预后差的潜在致死性疾病.在环境因素及遗传因素双重作用下发生体细胞基因突变而导致疾病状态,影像学可同时存在肺部肿物及蜂窝状改变.目前,特发性肺纤维化合并肺癌的发病机制尚不明确,临床表现缺乏特异性且预后差,中位生存期仅为6.9个月.临床医师应充分认识该疾病存在的可能性,争取早期诊断,优化治疗方案,综合干预以期提高患者的生活质量及生存期.

Idiopathic pulmonary fibrosis-lung cancer(IPF-LC)occurs predominantly in the male,elderly and smokers.It is a potentially fatal disease with poor prognosis and without special clinical features and clear treatment strategies.Due to environmental and genetic factors,somatic gene mutation lead to diseases.Imaging simultaneously shows both pulmonary masses and honeycomb changes.At present,besides the pathogenesis is still unkown,the clinical features are lack of specificity and the prognosis is poor with a 6.9 month median survival.Therefore,clinicians should fully understand the possibility of the disease,strive for early diagnosis,optimize treatment stratigies and intervene comprehensively to improve survival and the quality of life in IPF-LC patients.