摘要
血小板反应蛋白1(TSP1)是一种细胞基质糖蛋白.TSP1可通过调节细胞增殖、凋亡和黏附维持健康和体内平衡,抑制内皮迁移和增殖,促进活性氧产生,抑制移植创面愈合和血液流动.本文简单介绍了TSP1的发现及生物学影响因素,对TSP1与肺动脉高压的关系作一综述.
Thrombospondin-1(TSP1)is a cellular matrix glycoprotein.TSP1 maintains health and homeostasis by regulating cell proliferation,apoptosis and adhesion.TSP1 inhibits endothelial migration and proliferation,promotes reactive oxygen species production,and inhibits graft healing and blood flow.The article briefly introduces the discovery and its biological influencing factors,reviews the relationship between TSP1 and pulmonary hypertension.
作者
樊静雯
许小毛
Fan Jingwen;Xu Xiaomao(Department of Respiratory and Critical Care Medicine,Beijing Hospital,National Center of Gerontology,Beijing 100730,China)
出处
《国际呼吸杂志》
2019年第21期1675-1680,共6页
International Journal of Respiration
基金
“十三五”国家精准医学研究课题(2016YFC0905602)
“十二五”国家科技支撑计划(2011BAI11B17)。
