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沙格列汀联合格列美脲治疗2型糖尿病患者临床疗效分析 被引量:4

Clinical efficacy analysis of the combination of saxagliptin and glimepiride in the treatment of type 2 diabetes mellitus
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摘要 目的探讨沙格列汀联合格列美脲治疗2型糖尿病患者的临床疗效和安全性。方法将60例二甲双胍不敏感或不耐受其副作用的2型糖尿病患者随机分为观察组和对照组,每组30例,观察组给予沙格列汀联合格列美脲,对照组仅给予格列美脲,观察分析两组治疗前和治疗12周后空腹血糖、餐后2h血糖、糖化血红蛋白、BMI变化及低血糖发生情况。结果治疗前两组患者的各项指标差异均无统计学意义(P>0.05)。治疗后两组患者的FBG、PBG、HbA1c、BMI均较用药前明显降低(P<0.05),且观察组较对照组下降更显著(P<0.05),观察组不良反应发生率明显低于对照组。结论沙格列汀联合格列美脲对2型糖尿病二甲双胍失效或不耐受患者治疗效果显著,可有效改善患者体重,安全性高。 Objective To investigate the clinical efficacy and safety of combining use of saxagliptin and glimepiride in the treatment of type 2 diabetes mellitus.Methods Sixty patients with type 2 diabetes who were insensitive to metformin or intolerant of the side effects were randomly divided into observation group and control group,30 patients each.The observation group was treated with saxagliptin and glimepiride,while the control group was given glimepiride only.The changes of fasting blood glucose,2-hour postprandial blood glucose and glycosylated hemoglobin,as well as BMI were observed and analyzed before and 12 weeks after treatment,the occurrence of hypoglycemia also need to be recorded.Results There was no significant difference in the indexes between two groups before treatment(P>0.05).After treatment,FBG,PBG,HbA1 c and BMI of the two groups were significantly lower than before(P<0.05),the observation group decreased more significantly than the control group.The incidence of adverse reactions in the observation group was also lower than the control group(P<0.05).Conclusion Saxagliptin and glimepiride combination is an effective way to treat those patients with type 2 diabetes mellitus who are insensitive to metformin or intolerant of the side effects,and can effectively help losing weight with high safety.
作者 李肖肖 丁慧 郭世彪 LI Xiaoxiao;DING Hui;GUO Shibiao(Department of Internal Medicine,Weifang Medical University,Weifang 261053,China;Department of Health Care Section,Weifang People's Hospital;Department of Endocrinology,Weifang Yidu Central Hospital)
出处 《潍坊医学院学报》 2019年第5期389-391,共3页 Acta Academiae Medicinae Weifang
关键词 沙格列汀 格列美脲 二甲双胍不耐受 失效 2型糖尿病 Saglitine Glimepiride Metformin intolerance Failure Type 2 diabetes mellitus
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