不同化疗方案治疗局部进展期结直肠癌临床疗效的比较研究

A comparative study of the clinical efficacy of different chemotherapy regimens for locally advanced colorectal cancer

目的比较不同化疗方案治疗局部进展期结直肠癌的临床疗效。方法选取梧州市工人医院2015年1月-2018年1月收治的局部进展期结直肠癌患者70例,根据化疗方式分为对照组和观察组,各35例。对照组患者给予FOLFOX7化疗方案治疗,观察组患者给予XELOX化疗方案治疗。比较两组患者近期疗效,毒副作用及随访指标。结果观察组近期疗效总有效率高于对照组,毒副作用发生率低于对照组(P<0.05)。两组术后转移发生率、局部复发率、1年生存率比较,差异无统计学意义(P>0.05);观察组癌胚抗原(CEA)差值、糖抗原19-9(CA19-9)差值高于对照组(P<0.05)。结论与FOLFOX7化疗方案相比,XELOX化疗方案治疗局部进展期结直肠癌的临床疗效较好,安全性较高,但对提高术后生存率未见明显优势。

Objective To compare the clinical efficacy of different chemotherapy regimens for locally advanced colorectal cancer.Methods A total of 70 cases of patients with locally advanced colorectal cancer were selected from January 2015 to January 2018 in Wuzhou Worker’s Hospital,which were divided into control group and observation group according to the way of chemotherapy,35 cases in each group.The control group were treated with FOLFOX7 chemotherapy regimen,while the observation group were treated with XELOX chemotherapy regimen.The short-term efficacy,side effects and followup indicators were compared between the two groups.Results The observation group of short-term total effective rate was higher than the control group,and the incidence rate of toxic and side effects was lower than the control group(P<0.05).There was no significant difference in the incidence rate of metastasis and local,1-year survival rate between the two groups(P>0.05);the observation group of the difference of CEA and CA19-9 were higher than the control group(P<0.05).Conclusion Compared with FOLFOX7 regimen,XELOX regimen has better clinical efficacy and higher safety for locally advanced colorectal cancer,but it has no obvious advantage in improving the survival rate.