摘要
BACKGROUND Nitrous oxide(N2O)has gained increasing popularity as a recreational drug,causing hallucinations,excitation,and psychological dependence.However,side effects have been reported in recent years.Our case report proposes a correlation among N2O,pulmonary embolism(PE),and deep vein thrombosis(DVT)and emphasizes the role of homocysteine(Hcy)in thrombotic events.CASE SUMMARY A 29-year-old man with long-term N2O abuse sought evaluation after acute chest pain.A diagnostic workup revealed PE,DVT,and hyperhomocysteinemia.The patient was successfully treated with thrombolytic and anticoagulant therapy.Moreover,his Hcy level decreased and returned to normal after Hcy-lowering therapy.CONCLUSION Chronic N2O abuse might increase the risk of PE and DVT,although there have been few studies previously.
BACKGROUND Nitrous oxide（N2 O） has gained increasing popularity as a recreational drug,causing hallucinations, excitation, and psychological dependence. However, side effects have been reported in recent years. Our case report proposes a correlation among N2 O, pulmonary embolism（PE）, and deep vein thrombosis（DVT） and emphasizes the role of homocysteine（Hcy） in thrombotic events.CASE SUMMARY A 29-year-old man with long-term N2 O abuse sought evaluation after acute chest pain. A diagnostic workup revealed PE, DVT, and hyperhomocysteinemia. The patient was successfully treated with thrombolytic and anticoagulant therapy.Moreover, his Hcy level decreased and returned to normal after Hcy-lowering therapy.CONCLUSION Chronic N2 O abuse might increase the risk of PE and DVT, although there have been few studies previously.
