深板层角膜移植术治疗基质层角膜营养不良的效果

Efficacy of deep lamellar keratoplasty for the treatment of stromal corneal dystrophy

目的评估深板层角膜移植术治疗基质层角膜营养不良的临床效果。方法回顾性分析该院2012年1月至2018年12月收治的基质层角膜营养不良者49例(59只眼)的临床资料,所有患者采用深板层角膜移植术治疗。术后随访6个月~4年,观察术中、术后植片情况和并发症。结果术后角膜植片均透明。术后最佳矫正视力为0.3者8只眼,0.4~0.6者40只眼,0.6~0.8者11只眼。术中术后并发症包括:术中后弹力层穿孔5只眼,术后眼压升高4只眼,后弹力层皱褶6只眼,原发病复发3只眼。患者均无角膜移植术后排斥发生。结论深板层角膜移植术是治疗基质层角膜营养不良安全有效的手术方法。

Objective To evaluate the efficacy of deep lamellar keratoplasty for the treatment of stromal corneal dystrophy.Methods The data of 59 eyes of 49 patients with stromal corneal dystrophy in this hospital from Jan.2012 to Dec.2018 were analyzed retrospectively.All cases were treated with deep lamellar keratoplasty.The follow-up time was 6 months-4 years.The corneal graft and the complications of intra-operation and post-operation were observed.Results The corneal graft remained clear in all cases after surgery.The best corrected visual acuity(BCVA)postoperatively was 0.3 in 8 eyes,0.4-0.6 in 40 eyes,0.6-0.8 in 11 eyes.Intraoperative complications included perforation of descemet’s membrane in 5 eyes,postoperative temporary elevation of intraocular pressure in 4 eyes,descemet’s membrane striae in 6 cases and recurrence of primary disease in 3 eyes.No reject reaction occurred after keratoplasty.Conclusion Deep lamellar keratoplasty is a safe and effective method for the treatment of stromal corneal dystrophy.