光学相干断层扫描血管成像在治疗黄斑变性随访中的作用

The role of optical coherence tomographic angiography in the treatment and follow-up of macular degeneration

目的评估光学相干断层扫描血管成像(OCTA)在抗VEGF药物治疗新生血管性年龄相关性黄斑变性(nAMD)随访中的作用。方法回顾性分析2018年5月至2018年10月郑州市第二人民医院眼科玻璃体内注射雷珠单抗治疗的nAMD共33例(41眼)的临床资料,治疗前后均行光学相干断层扫描(OCT)及OCTA检查,随访6个月。结果治疗后6个月OCT及OCTA结果显示中心视网膜厚度较治疗前下降(t=31.454,P=0.000),脉络膜新血管形成(CNV)血流面积较治疗前缩小(t=4.117,P=0.000),其中密集型较稀疏型CNV血流面积减少更明显(Z=3.686,P=0.000)。结论OCTA检查可动态检测CNV的形态及血流面积变化,在nAMD的治疗随访中有重要意义。

Objective To evaluate the role of optical coherence tomographic angiography(OCTA)in anti-vascular endothelial growth factor(VEGF)treating the neovascular age-related macular degeneration(nAMD)and follow-up.Methods Total of 41 eyes of 33 patients with nAMD in the Second People’s Hospital of Zhengzhou from May 2018 to Oct.2018 were analyzed retrospectively.All cases were treated with intravitreal injection of ranibizumab(IVR).All cases were followed up for 6 months.Results At 6 months after treatment,the OCT and OCTA showed the average central retinat thickness reduced(t=31.454,P=0.000),and CNV flow areas shrinked after IVR(t=4.117,P=0.000).The decrease of CNV flow areas in eyes with dense-network CNV was more obvious than that in loose-network CNV(Z=3.686,P=0.000).Conclusion OCTA is a reliable method to observe dynamically the strutures and quantified the blood flow area of CNV.It is significant in treatment and follow-up evaluation of nAMD.